“It is time for IBS to be recognized as a legitimate condition that can benefit from new theories and treatment strategies.”
– Dr. Mark Pimentel
On August 2, 2018, FODMAP Life will be holding a Facebook LIVE interview with Dr. Mark Pimentel, discussing all things IBS, SIBO, and the gut microbiome. Join us at 3 p.m. PST to join in on the conversation and ask questions. Whether you are a patient, loved one of a patient, dietitian or gastroenterologist, you will come away learning something new.
Dr. Pimentel is currently the head of the Pimentel Laboratory and executive director of the Medically Associated Science and Technology (MAST) Program at Cedars-Sinai. This program focuses on the development of drugs, diagnostic tests and devices related to conditions of the microbiome.
In the past, there was no definitive test to diagnose IBS. For a time, IBS was thought to be a psychological disease; however, the Pimentel Lab discovered a blood test to provide a definitive diagnosis showing that IBS is an organic disease. Having a definitive diagnosis for IBS paved the way for additional research in the Pimentel Lab to treat the condition. – The Pimentel Laboratory
Dr. Pimentel is one of the thought leaders in the IBS, SIBO and gut microbiome space. In his book, A New IBS Solution: Bacteria-The Missing Link in Treating Irritable Bowel Syndrome, Health Point Press, Dr. Pimentel believes that the root cause of most IBS symptoms can be attributed to an overgrowth of bacteria in the small intestine. Dr. Pimentel presents a simple treatment protocol to help resolve IBS symptoms, and prevent recurrence. In this book, he has highlighted the latest discoveries in IBS that are rational and scientifically proven. He discusses the latest developments surrounding the association between IBS and gut bacteria.
“There is a distinct relationship between having acute gastroenteritis (food poisoning or travelers’ diarrhea) and the development of IBS. A significant percentage of people who get an infectious case of diarrhea will go on to develop IBS, suggesting that in certain cases of IBS, food poisoning is the cause. In this book we discussed the case for food poisoning in precipitating IBS and what to do about it. More important, this book has summarized the data showing that most IBS patients test positive for bacterial overgrowth. This is a situation whereby bacteria that are commonly found in the large intestine now also inhabit parts of the usually sterile small intestine, leading to the symptoms of IBS. The evidence presented demonstrates how treatment of bacterial overgrowth dramatically improves IBS. We call this technique the Cedars-Sinai protocol for IBS. “The hope is that this book empowers those with IBS to realize there is reason for optimism, reason to stop suffering in silence, reason to stop “living” with IBS, and reason to think about treating IBS again.” (pp. 131-132)
A few of the most significant accomplishments of the Pimentel Laboratory include:
- The discovery of rifaximin as a treatment for irritable bowel syndrome (IBS) with diarrhea
- Developing the first blood test for IBS on the basis of IBS being derived from acute gastroenteritis
- Describing the association between IBS and small intestinal bacterial overgrowth (SIBO), which forms the basis for microbiome therapies in this condition
- Determining IBS/SIBO to be an autoimmune disease
- Developing the first animal model to study treatment of IBS/SIBO caused by gastroenteritis
- Uncovering the methanogen Methanobrevibacter smithii (M. smithii) as an agent for causing constipation in humans
- Discovering the use of lovastatin as a microbiome treatment for constipation on the basis of inhibiting methane production by methanogens
FACEBOOK LIVE INTERVIEW WITH DR. PIMENTEL
August 2, 2018, at 3:00 p.m. PST. Join us on Facebook
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Colleen Francioli, Founder, FODMAP Life